The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5A...
Published in: | Nature Genetics |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Pub. Co.
2009
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/56397 https://doi.org/10.1038/ng1311 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/56397 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/56397 2023-05-15T16:50:09+02:00 The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, Anna Manolescu, Andrei Thorleifsson, Gudmar Gretarsdottir, Solveig Jonsdottir, Helga Thorsteinsdottir, Unnur Samani, Nilesh J Gudmundsson, Gudmundur Grant, Struan F A Thorgeirsson, Gudmundur Sveinbjornsdottir, Sigurlaug Valdimarsson, Einar M Matthiasson, Stefan E Johannsson, Halldor Gudmundsdottir, Olof Gurney, Mark E Sainz, Jesus Thorhallsdottir, Margret Andresdottir, Margret Frigge, Michael L Topol, Eric J Kong, Augustine Gudnason, Vilmundur Hakonarson, Hakon Gulcher, Jeffrey R Stefansson, Kari deCODE genetics, Sturlugata 8, Reykjavik, Iceland. 2009-03-19 http://hdl.handle.net/2336/56397 https://doi.org/10.1038/ng1311 en eng Nature Pub. Co. http://dx.doi.org/10.1038/ng1311 Nat. Genet. 2004, 36(3):233-9 1061-4036 14770184 doi:10.1038/ng1311 http://hdl.handle.net/2336/56397 Nature genetics Carrier Proteins Chromosome Mapping Chromosomes Human Pair 13 Genetic Predisposition to Disease Humans Leukotriene B4 Membrane Proteins Microsatellite Repeats Myocardial Infarction Polymorphism Single Nucleotide Stroke Article 2009 ftlandspitaliuni https://doi.org/10.1038/ng1311 2022-05-29T08:21:17Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 36 3 233 239 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Carrier Proteins Chromosome Mapping Chromosomes Human Pair 13 Genetic Predisposition to Disease Humans Leukotriene B4 Membrane Proteins Microsatellite Repeats Myocardial Infarction Polymorphism Single Nucleotide Stroke |
spellingShingle |
Carrier Proteins Chromosome Mapping Chromosomes Human Pair 13 Genetic Predisposition to Disease Humans Leukotriene B4 Membrane Proteins Microsatellite Repeats Myocardial Infarction Polymorphism Single Nucleotide Stroke Helgadottir, Anna Manolescu, Andrei Thorleifsson, Gudmar Gretarsdottir, Solveig Jonsdottir, Helga Thorsteinsdottir, Unnur Samani, Nilesh J Gudmundsson, Gudmundur Grant, Struan F A Thorgeirsson, Gudmundur Sveinbjornsdottir, Sigurlaug Valdimarsson, Einar M Matthiasson, Stefan E Johannsson, Halldor Gudmundsdottir, Olof Gurney, Mark E Sainz, Jesus Thorhallsdottir, Margret Andresdottir, Margret Frigge, Michael L Topol, Eric J Kong, Augustine Gudnason, Vilmundur Hakonarson, Hakon Gulcher, Jeffrey R Stefansson, Kari The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
topic_facet |
Carrier Proteins Chromosome Mapping Chromosomes Human Pair 13 Genetic Predisposition to Disease Humans Leukotriene B4 Membrane Proteins Microsatellite Repeats Myocardial Infarction Polymorphism Single Nucleotide Stroke |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall. |
author2 |
deCODE genetics, Sturlugata 8, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Helgadottir, Anna Manolescu, Andrei Thorleifsson, Gudmar Gretarsdottir, Solveig Jonsdottir, Helga Thorsteinsdottir, Unnur Samani, Nilesh J Gudmundsson, Gudmundur Grant, Struan F A Thorgeirsson, Gudmundur Sveinbjornsdottir, Sigurlaug Valdimarsson, Einar M Matthiasson, Stefan E Johannsson, Halldor Gudmundsdottir, Olof Gurney, Mark E Sainz, Jesus Thorhallsdottir, Margret Andresdottir, Margret Frigge, Michael L Topol, Eric J Kong, Augustine Gudnason, Vilmundur Hakonarson, Hakon Gulcher, Jeffrey R Stefansson, Kari |
author_facet |
Helgadottir, Anna Manolescu, Andrei Thorleifsson, Gudmar Gretarsdottir, Solveig Jonsdottir, Helga Thorsteinsdottir, Unnur Samani, Nilesh J Gudmundsson, Gudmundur Grant, Struan F A Thorgeirsson, Gudmundur Sveinbjornsdottir, Sigurlaug Valdimarsson, Einar M Matthiasson, Stefan E Johannsson, Halldor Gudmundsdottir, Olof Gurney, Mark E Sainz, Jesus Thorhallsdottir, Margret Andresdottir, Margret Frigge, Michael L Topol, Eric J Kong, Augustine Gudnason, Vilmundur Hakonarson, Hakon Gulcher, Jeffrey R Stefansson, Kari |
author_sort |
Helgadottir, Anna |
title |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
title_short |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
title_full |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
title_fullStr |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
title_full_unstemmed |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
title_sort |
gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. |
publisher |
Nature Pub. Co. |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/56397 https://doi.org/10.1038/ng1311 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1038/ng1311 Nat. Genet. 2004, 36(3):233-9 1061-4036 14770184 doi:10.1038/ng1311 http://hdl.handle.net/2336/56397 Nature genetics |
op_doi |
https://doi.org/10.1038/ng1311 |
container_title |
Nature Genetics |
container_volume |
36 |
container_issue |
3 |
container_start_page |
233 |
op_container_end_page |
239 |
_version_ |
1766040334849015808 |