The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5A...

Full description

Bibliographic Details
Published in:Nature Genetics
Main Authors: Helgadottir, Anna, Manolescu, Andrei, Thorleifsson, Gudmar, Gretarsdottir, Solveig, Jonsdottir, Helga, Thorsteinsdottir, Unnur, Samani, Nilesh J, Gudmundsson, Gudmundur, Grant, Struan F A, Thorgeirsson, Gudmundur, Sveinbjornsdottir, Sigurlaug, Valdimarsson, Einar M, Matthiasson, Stefan E, Johannsson, Halldor, Gudmundsdottir, Olof, Gurney, Mark E, Sainz, Jesus, Thorhallsdottir, Margret, Andresdottir, Margret, Frigge, Michael L, Topol, Eric J, Kong, Augustine, Gudnason, Vilmundur, Hakonarson, Hakon, Gulcher, Jeffrey R, Stefansson, Kari
Other Authors: deCODE genetics, Sturlugata 8, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Nature Pub. Co. 2009
Subjects:
Carrier Proteins
Chromosome Mapping
Chromosomes
Human
Pair 13
Genetic Predisposition to Disease
Humans
Leukotriene B4
Membrane Proteins
Microsatellite Repeats
Myocardial Infarction
Polymorphism
Single Nucleotide
Stroke
Iceland
Online Access:http://hdl.handle.net/2336/56397
https://doi.org/10.1038/ng1311
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.

Similar Items