Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa
Recent study demonstrated that dietary eicosapentaenoic acid (EPA) could alleviate metabolism disorders. However, the onset time of EPA-enriched phospholipid (EPA-PL) on lipid metabolism was rarely been reported. The aim of the present study was to evaluate the time-dependent changes in lipid profil...
Published in: | Journal of Functional Foods |
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Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
2017
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Subjects: | |
Online Access: | https://doi.org/10.1016/j.jff.2016.10.022 https://doaj.org/article/dabfc9e77fa144a4b524c6560d859ca4 |
Summary: | Recent study demonstrated that dietary eicosapentaenoic acid (EPA) could alleviate metabolism disorders. However, the onset time of EPA-enriched phospholipid (EPA-PL) on lipid metabolism was rarely been reported. The aim of the present study was to evaluate the time-dependent changes in lipid profile and genes of lipometabolism induced by EPA-PL from Cucumaria frondosa. Male C57BL/6J mice were fed a standard diet with or without EPA-PL for 3, 7, or 14 days. Additionally, we examined gene expression 1 week after removing EPA-PL from the diet. Our results indicated that 3-day EPA-PL supplementation significantly increased the expression of genes related to β-oxidation (UCP2, Ehhadh, Acaa1) in the liver and epididymal adipose tissue, whereas no differences were observed in the mRNA expression of selected genes between groups 1 week after EPA-PL removal. It is concluded that EPA-PL served as a rapid regulator of fat burning and could be a functional food for obesity disorders. |
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