Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa

Recent study demonstrated that dietary eicosapentaenoic acid (EPA) could alleviate metabolism disorders. However, the onset time of EPA-enriched phospholipid (EPA-PL) on lipid metabolism was rarely been reported. The aim of the present study was to evaluate the time-dependent changes in lipid profil...

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Bibliographic Details
Published in:Journal of Functional Foods
Main Authors: Lingyu Zhang, Dan Wang, Min Wen, Lei Du, Changhu Xue, Jingfeng Wang, Jie Xu, Yuming Wang
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2017
Subjects:
Short-term
EPA-enriched phospholipid
β-Oxidation
Lipid metabolism
Reversal
Nutrition. Foods and food supply
TX341-641
Cucumaria frondosa
Online Access:https://doi.org/10.1016/j.jff.2016.10.022
https://doaj.org/article/dabfc9e77fa144a4b524c6560d859ca4
Description
Summary:Recent study demonstrated that dietary eicosapentaenoic acid (EPA) could alleviate metabolism disorders. However, the onset time of EPA-enriched phospholipid (EPA-PL) on lipid metabolism was rarely been reported. The aim of the present study was to evaluate the time-dependent changes in lipid profile and genes of lipometabolism induced by EPA-PL from Cucumaria frondosa. Male C57BL/6J mice were fed a standard diet with or without EPA-PL for 3, 7, or 14 days. Additionally, we examined gene expression 1 week after removing EPA-PL from the diet. Our results indicated that 3-day EPA-PL supplementation significantly increased the expression of genes related to β-oxidation (UCP2, Ehhadh, Acaa1) in the liver and epididymal adipose tissue, whereas no differences were observed in the mRNA expression of selected genes between groups 1 week after EPA-PL removal. It is concluded that EPA-PL served as a rapid regulator of fat burning and could be a functional food for obesity disorders.

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