Search Results

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

by Diego Benítez, Andrea Medeiros, Lucía Fiestas, Esteban A Panozzo-Zenere, Franziska Maiwald, Kyriakos C Prousis, Marina Roussaki, Theodora Calogeropoulou, Anastasia Detsi, Timo Jaeger, Jonas Šarlauskas, Lucíja Peterlin Mašič, Conrad Kunick, Guillermo R Labadie, Leopold Flohé, Marcelo A Comini
Published in PLOS Neglected Tropical Diseases (2016)

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.

by Jair L Siqueira-Neto, Ok-Ryul Song, Hyunrim Oh, Jeong-Hun Sohn, Gyongseon Yang, Jiyoun Nam, Jiyeon Jang, Jonathan Cechetto, Chang Bok Lee, Seunghyun Moon, Auguste Genovesio, Eric Chatelain, Thierry Christophe, Lucio H Freitas-Junior
Published in PLoS Neglected Tropical Diseases (2010)

Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication.

by V Haridas, Kullampalayam Shanmugam Rajgokul, Sandhya Sadanandan, Tanvi Agrawal, Vats Sharvani, M V S Gopalakrishna, M B Bijesh, Kanhaiya Lal Kumawat, Anirban Basu, Guruprasad R Medigeshi
Published in PLoS Neglected Tropical Diseases (2013)

Unravelling the rate of action of hits in the Leishmania donovani box using standard drugs amphotericin B and miltefosine.

by Diana Tegazzini, Juan Cantizani, Imanol Peña, Julio Martín, Jose M Coterón
Published in PLOS Neglected Tropical Diseases (2017)

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

by Tony Taldone, Victoria Gillan, Weilin Sun, Anna Rodina, Pallav Patel, Kirsty Maitland, Kerry O'Neill, Gabriela Chiosis, Eileen Devaney
Published in PLoS Neglected Tropical Diseases (2010)

Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.

by Leandro A A Avelar, Cristian D Camilo, Sérgio de Albuquerque, William B Fernandes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, James H McKerrow, Carlos A Montanari, Erika V Meñaca Orozco, Jean F R Ribeiro, Josmar R Rocha, Fabiana Rosini, Marta E Saidel
Published in PLOS Neglected Tropical Diseases (2015)

Ergot Alkaloids (Re)generate New Leads as Antiparasitics.

by John D Chan, Prince N Agbedanu, Thomas Grab, Mostafa Zamanian, Peter I Dosa, Timothy A Day, Jonathan S Marchant
Published in PLOS Neglected Tropical Diseases (2015)

Assembly of the genome of the disease vector Aedes aegypti onto a genetic linkage map allows mapping of genes affecting disease transmission.

by Punita Juneja, Jewelna Osei-Poku, Yung S Ho, Cristina V Ariani, William J Palmer, Arnab Pain, Francis M Jiggins
Published in PLoS Neglected Tropical Diseases (2014)

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

by Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo, Cristina Alli, Giacomo Paonessa, Gianni Colotti, Steven Harper, Annarita Fiorillo, Andrea Ilari, Alberto Bresciani
Published in PLOS Neglected Tropical Diseases (2020)

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

by Chiung-Kuang Chen, Patricia S Doyle, Liudmila V Yermalitskaya, Zachary B Mackey, Kenny K H Ang, James H McKerrow, Larissa M Podust
Published in PLoS Neglected Tropical Diseases (2009)

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.

by Andrew P Jackson, Mandy Sanders, Andrew Berry, Jacqueline McQuillan, Martin A Aslett, Michael A Quail, Bridget Chukualim, Paul Capewell, Annette MacLeod, Sara E Melville, Wendy Gibson, J David Barry, Matthew Berriman, Christiane Hertz-Fowler
Published in PLoS Neglected Tropical Diseases (2010)

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

by Gregory J Crowther, Michael L Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F Novelli, Panqing He, Natalie R G Dale, Amy M Fife, Robert H Barker, Martin L Kramer, Wesley C Van Voorhis, Clotilde K S Carlow, Ming-Wei Wang
Published in PLoS Neglected Tropical Diseases (2014)

An improved genome assembly of the fluke Schistosoma japonicum.

by Fang Luo, Mingbo Yin, Xiaojin Mo, Chengsong Sun, Qunfeng Wu, Bingkuan Zhu, Manyu Xiang, Jipeng Wang, Yi Wang, Jian Li, Ting Zhang, Bin Xu, Huajun Zheng, Zheng Feng, Wei Hu
Published in PLOS Neglected Tropical Diseases (2019)

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.

by Harry F Williams, Ben A Mellows, Robert Mitchell, Peggy Sfyri, Harry J Layfield, Maryam Salamah, Rajendran Vaiyapuri, Henry Collins-Hooper, Andrew B Bicknell, Antonios Matsakas, Ketan Patel, Sakthivel Vaiyapuri
Published in PLOS Neglected Tropical Diseases (2019)

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans.

by Andres Garcia-Campos, Alessandra Ravidà, D Linh Nguyen, Krystyna Cwiklinski, John P Dalton, Cornelis H Hokke, Sandra O'Neill, Grace Mulcahy
Published in PLOS Neglected Tropical Diseases (2016)

Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development.

by Li Li, Bing Chen, Hongbin Yan, Yannan Zhao, Zhongzi Lou, Jianqiu Li, Baoquan Fu, Xingquan Zhu, Donald P McManus, Jianwu Dai, Wanzhong Jia
Published in PLOS Neglected Tropical Diseases (2018)

Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.

by Deu John M Cruz, Rafaela M Bonotto, Rafael G B Gomes, Camila T da Silva, Juliana B Taniguchi, Joo Hwan No, Benoit Lombardot, Olivier Schwartz, Michael A E Hansen, Lucio H Freitas-Junior
Published in PLoS Neglected Tropical Diseases (2013)

Building cultural responsiveness in a mainstream health organisation with ‘8 Aboriginal Ways of Learning’: a participatory action research study

by Emma Webster, Allan Hall (Yuwaallaraay/Gamilaroi), Yvonne Hill (Wiradjuri), Cecil See (Wiradjuri), Eunice Simons, Rachael Havrlant, Regina Osten
Published in Australian and New Zealand Journal of Public Health (2022)

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.

by Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha
Published in PLOS Neglected Tropical Diseases (2017)

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.

by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de Sande
Published in PLOS Neglected Tropical Diseases (2022)