In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-...

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Bibliographic Details
Published in:Environmental Science & Technology
Main Authors: Gutleb, A.C., Cenijn, P.H., van Velzen, P., Lie, E., Ropstad, E., Skaare, J.U., Malmberg, T., Bergman, A., Gabrielsen, G. W., Legler, J.
Format: Article in Journal/Newspaper
Language:English
Published: 2010
Subjects:
/dk/atira/pure/sustainabledevelopmentgoals/life_below_water
name=SDG 14 - Life Below Water
Arctic
Ursus maritimus
Online Access:https://research.vu.nl/en/publications/e5323fa4-fd2e-4c02-9df4-f716be73d45b
https://doi.org/10.1021/es903029j
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Summary:Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [

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