Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection

Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins suc...

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Bibliographic Details
Published in:Antibiotics
Main Authors: Aguilera-Correa, John Jairo, Fernández-López, Sara, Cuñas-Figueroa, Iskra Dennisse, Pérez-Rial, Sandra, Alakomi, Hanna Leena, Nohynek, Liisa, Oksman-Caldentey, Kirsi Marja, Salminen, Juha Pekka, Esteban, Jaime, Cuadros, Juan, Puupponen-Pimiä, Riitta, Perez-Tanoira, Ramon, Kinnari, Teemu J.
Format: Article in Journal/Newspaper
Language:English
Published: 2021
Subjects:
Biofilm
Cloudberry
Ellagitannin
Methicillin-resistant S. aureus
Rubus
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
name=SDG 3 - Good Health and Well-being
Rubus chamaemorus
Online Access:https://cris.vtt.fi/en/publications/be68e325-e776-489a-a3d1-9cfa9d81fe9c
https://doi.org/10.3390/antibiotics10121481
https://cris.vtt.fi/ws/files/54823680/antibiotics10121481.pdf
http://www.scopus.com/inward/record.url?scp=85121577670&partnerID=8YFLogxK
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Summary:Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.

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