Hydrogen bond template-directed polymerization of protected 5 '-acryloylnucleosides
Poly(5'-acryloyluridine) has been shown to act as a template in the radical polymerization of the complementary 5'-acryloyladenosine in the presence of the noncomplementary 5'-acryloyluridine. The template was synthesized by polymerizing 5'-acryloyluridine using AIBN as the initi...
| Format: | Article in Journal/Newspaper |
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| Language: | unknown |
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AMER CHEMICAL SOC
1999
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| Subjects: | |
| Online Access: | http://wrap.warwick.ac.uk/14116/ |
| Summary: | Poly(5'-acryloyluridine) has been shown to act as a template in the radical polymerization of the complementary 5'-acryloyladenosine in the presence of the noncomplementary 5'-acryloyluridine. The template was synthesized by polymerizing 5'-acryloyluridine using AIBN as the initiator. The 5'-acryloylnucleosides were synthesized by regiospecific acylation of adenosine and uridine at the 5'-position using the enzyme Candida antarctica lipase 435 (CAL 435). The remaining hydroxyl groups were protected as silyl ethers to increase the solubility in nonpolar solvents. |
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