Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

• Published in: Journal of Natural Products
• Main Authors: Thomas, Santana A. L., von Salm, Jacqueline L., Clark, Shane, Ferlita, Steve, Nemani, Prasanth, Azhari, Ala, Rice, Christopher A., Wilson, Nerida G., Kyle, Dennis E., Baker, Bill J.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Digital Commons @ University of South Florida 2018
• Subjects: Antarctic; Southern Ocean; The Antarctic; Antarc*
• Online Access: https://digitalcommons.usf.edu/chm_facpub/100; https://doi.org/10.1021/acs.jnatprod.7b00732

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2–7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.