Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isol...

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Bibliographic Details
Published in:Journal of Natural Products
Main Authors: Thomas, Santana A. L., von Salm, Jacqueline L., Clark, Shane, Ferlita, Steve, Nemani, Prasanth, Azhari, Ala, Rice, Christopher A., Wilson, Nerida G., Kyle, Dennis E., Baker, Bill J.
Format: Article in Journal/Newspaper
Language:unknown
Published: Digital Commons @ University of South Florida 2018
Subjects:
Antarctic
Southern Ocean
The Antarctic
Antarc*
Online Access:https://digitalcommons.usf.edu/chm_facpub/100
https://doi.org/10.1021/acs.jnatprod.7b00732
Description
Summary:During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2–7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

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