Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter

• Main Author: Zemlyaniy, Ya. V.
• Format: Article in Journal/Newspaper
• Language: Ukrainian
• Published: Zaporizhzhia State Medical and Pharmaceutical University 2014
• Subjects: heart failure with preserved ejection fraction; candesartan; ramipril; myocardial infarction; hypertension; сердечная недостаточность с сохраненной фракцией выброса; кандесартан; рамиприл; инфаркт миокарда; артериальная гипертензия; серцева недостатність зі збереженою фракцією викиду; раміприл; інфаркт міокарда; артеріальна гіпертензія; Iceland
• Online Access: http://zmj.zsmu.edu.ua/article/view/25232

Abstract. Chronic heart failure (CHF) is actual medical problem around the world and in Ukraine. Almost 50% of these patients have heart failure with preserved ejection fraction. CHF is the result of many complications and cardiovascular disease, such as coronary heart disease, including myocardial infarction and hypertension. Despite the prevalence of heart failure with preserved ejection fraction a common strategy for the treatment of this disease has not yet been developed. This is due to the limited number of controlled studies in these patients. One of the most effective drugs in the treatment of heart failure with preserved ejection fraction after myocardial infarction are candesartan and ramipril. Determining the dynamics of GDF 15 and NTproBNP along with those of echocardiography is promising for evaluating the effectiveness of treatment of patients with heart failure with preserved ejection fraction after myocardial infarction in the background of arterial hypertension.The aim of research. To determine the dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy in patients with heart failure and preserved ejection fraction after myocardial infarction on the background of arterial hypertension.Materials and methods. 38 patients with heart failure with preserved left ventricular ejection fraction (EF>45%) after myocardial infarction with comorbidity arterial hypertension were included into the study. Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy for 12 weeks (mean age 64,3 ± 1,3 years) were investigated. Prescription myocardial infarction ranged from 2 months to 3 years. Patients were divided into 2 groups. The first group in addition to the basic treatment received candesartan (KASARK "Arterium", Ukraine) at a mean dose 18,5 ± 2,1 mg daily. Patients of the second group received ramipril (RAMIMED, «Medochemie Ltd.», Iceland/Cyprus) ...