The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum
Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and...
Published in: | Journal of Experimental Biology |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2005
|
Subjects: | |
Online Access: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/the-role-of-myostain-and-the-calcineurinsignalling-pathway-in-regulating-muscle-mass-in-response-to-exercise-training-in-the-rainbow-trout-oncorhynchus-mykiss-walbaum(868215c6-4cd1-437e-9b89-bfb05b4d55b2).html https://doi.org/10.1242/jeb.01605 http://www.scopus.com/inward/record.url?scp=20744444140&partnerID=8YFLogxK |
id |
ftunstandrewcris:oai:risweb.st-andrews.ac.uk:publications/868215c6-4cd1-437e-9b89-bfb05b4d55b2 |
---|---|
record_format |
openpolar |
spelling |
ftunstandrewcris:oai:risweb.st-andrews.ac.uk:publications/868215c6-4cd1-437e-9b89-bfb05b4d55b2 2023-05-15T15:32:24+02:00 The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum Martin, C I Johnston, Ian Alistair 2005-06 https://risweb.st-andrews.ac.uk/portal/en/researchoutput/the-role-of-myostain-and-the-calcineurinsignalling-pathway-in-regulating-muscle-mass-in-response-to-exercise-training-in-the-rainbow-trout-oncorhynchus-mykiss-walbaum(868215c6-4cd1-437e-9b89-bfb05b4d55b2).html https://doi.org/10.1242/jeb.01605 http://www.scopus.com/inward/record.url?scp=20744444140&partnerID=8YFLogxK eng eng info:eu-repo/semantics/restrictedAccess Martin , C I & Johnston , I A 2005 , ' The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum ' , Journal of Experimental Biology , vol. 208 , pp. 2083-2090 . https://doi.org/10.1242/jeb.01605 rainbow trout Oncorhynchus mykiss exercise muscle hypertrophy calcineurin NFAT2 myostatin HUMAN SKELETAL-MUSCLE TRANSCRIPTION FACTORS ATLANTIC SALMON HEALTHY-MEN BROOK TROUT EXPRESSION GROWTH PROTEINS GENE article 2005 ftunstandrewcris https://doi.org/10.1242/jeb.01605 2021-12-26T14:13:30Z Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout. Article in Journal/Newspaper Atlantic salmon University of St Andrews: Research Portal Journal of Experimental Biology 208 11 2083 2090 |
institution |
Open Polar |
collection |
University of St Andrews: Research Portal |
op_collection_id |
ftunstandrewcris |
language |
English |
topic |
rainbow trout Oncorhynchus mykiss exercise muscle hypertrophy calcineurin NFAT2 myostatin HUMAN SKELETAL-MUSCLE TRANSCRIPTION FACTORS ATLANTIC SALMON HEALTHY-MEN BROOK TROUT EXPRESSION GROWTH PROTEINS GENE |
spellingShingle |
rainbow trout Oncorhynchus mykiss exercise muscle hypertrophy calcineurin NFAT2 myostatin HUMAN SKELETAL-MUSCLE TRANSCRIPTION FACTORS ATLANTIC SALMON HEALTHY-MEN BROOK TROUT EXPRESSION GROWTH PROTEINS GENE Martin, C I Johnston, Ian Alistair The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
topic_facet |
rainbow trout Oncorhynchus mykiss exercise muscle hypertrophy calcineurin NFAT2 myostatin HUMAN SKELETAL-MUSCLE TRANSCRIPTION FACTORS ATLANTIC SALMON HEALTHY-MEN BROOK TROUT EXPRESSION GROWTH PROTEINS GENE |
description |
Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout. |
format |
Article in Journal/Newspaper |
author |
Martin, C I Johnston, Ian Alistair |
author_facet |
Martin, C I Johnston, Ian Alistair |
author_sort |
Martin, C I |
title |
The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
title_short |
The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
title_full |
The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
title_fullStr |
The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
title_full_unstemmed |
The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum |
title_sort |
role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout oncorhynchus mykiss walbaum |
publishDate |
2005 |
url |
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/the-role-of-myostain-and-the-calcineurinsignalling-pathway-in-regulating-muscle-mass-in-response-to-exercise-training-in-the-rainbow-trout-oncorhynchus-mykiss-walbaum(868215c6-4cd1-437e-9b89-bfb05b4d55b2).html https://doi.org/10.1242/jeb.01605 http://www.scopus.com/inward/record.url?scp=20744444140&partnerID=8YFLogxK |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Martin , C I & Johnston , I A 2005 , ' The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum ' , Journal of Experimental Biology , vol. 208 , pp. 2083-2090 . https://doi.org/10.1242/jeb.01605 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1242/jeb.01605 |
container_title |
Journal of Experimental Biology |
container_volume |
208 |
container_issue |
11 |
container_start_page |
2083 |
op_container_end_page |
2090 |
_version_ |
1766362897840078848 |