The role of myostain and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum

Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and...

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Bibliographic Details
Published in:Journal of Experimental Biology
Main Authors: Martin, C I, Johnston, Ian Alistair
Format: Article in Journal/Newspaper
Language:English
Published: 2005
Subjects:
rainbow trout
Oncorhynchus mykiss
exercise
muscle
hypertrophy
calcineurin
NFAT2
myostatin
HUMAN SKELETAL-MUSCLE
TRANSCRIPTION FACTORS
ATLANTIC SALMON
HEALTHY-MEN
BROOK TROUT
EXPRESSION
GROWTH
PROTEINS
GENE
Atlantic salmon
Online Access:https://risweb.st-andrews.ac.uk/portal/en/researchoutput/the-role-of-myostain-and-the-calcineurinsignalling-pathway-in-regulating-muscle-mass-in-response-to-exercise-training-in-the-rainbow-trout-oncorhynchus-mykiss-walbaum(868215c6-4cd1-437e-9b89-bfb05b4d55b2).html
https://doi.org/10.1242/jeb.01605
http://www.scopus.com/inward/record.url?scp=20744444140&partnerID=8YFLogxK
Description
Summary:Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout.

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