Effects of angiotensin II and C-type natriuretic peptide on the in situ perfused trunk preparation of the dogfish, Scyliorhinus canicula

The renal roles of physiologically relevant doses of angiotensin II (Ang II) and C-type natriuretic peptide (CNP) were investigated in the dogfish, Scyliorhinus canicula, using an in situ perfused trunk preparation. Perfusion with 10(-9) M Ang II resulted in a glomerular antidiuresis and decreases i...

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Bibliographic Details
Published in:General and Comparative Endocrinology
Main Authors: Wells, A, Anderson, W G, Cains, J E, Cooper, M W, Hazon, N
Format: Article in Journal/Newspaper
Language:English
Published: 2006
Subjects:
antidiuresis
diuresis
seawater
Scyliorhinus canicula
dogfish
glomerular perfusion patterns
LESSER-SPOTTED DOGFISH
ELASMOBRANCH FISH
MARINE ELASMOBRANCH
SQUALUS-ACANTHIAS
MOLECULAR-FORMS
TRIAKIS-SCYLLIA
SPINY DOGFISH
KIDNEY
SYSTEM
HEART
Canicula
spiny dogfish
Squalus acanthias
Online Access:https://risweb.st-andrews.ac.uk/portal/en/researchoutput/effects-of-angiotensin-ii-and-ctype-natriuretic-peptide-on-the-in-situ-perfused-trunk-preparation-of-the-dogfish-scyliorhinus-canicula(5bf9608f-3dd4-42a4-8def-d578152fa239).html
https://doi.org/10.1016/j.ygcen.2005.08.002
http://www.scopus.com/inward/record.url?scp=29344461293&partnerID=8YFLogxK
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Summary:The renal roles of physiologically relevant doses of angiotensin II (Ang II) and C-type natriuretic peptide (CNP) were investigated in the dogfish, Scyliorhinus canicula, using an in situ perfused trunk preparation. Perfusion with 10(-9) M Ang II resulted in a glomerular antidiuresis and decreases in perfusate flow rate, transport maxima for glucose and the proportion of filtering glomeruli. In addition, the renal clearances and excretion of urea, sodium, and chloride were significantly reduced, whereas the relative clearances of these parameters remained unchanged. In contrast, perfusion of 10(-9) M CNP caused a glomerular diuresis, an increase in transport maxima for glucose, but no significant change in the proportion of filtering glomeruli. In addition, the renal clearances of urea, sodium, and chloride were significantly increased but there was no effect on the relative clearances of urea, sodium, or chloride. Perfusion with 10(-10) M Ang II or CNP had no significant renal effects. Our results suggest that these hormones act at the level of the glomeruli rather than at a tubular level. (c) 2005 Elsevier Inc. All rights reserved.

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