Synthesis of the Originally Proposed Structure of Palmerolide C
A stereoselective synthesis of the proposed structure of palmerolide C (2), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum adareanum, utilizes a convergent carbonyl-based coupling strategy to construct the C1-C24 carbon skeleton. Compound 2 was shown to be a diastereomer...
Published in: | Chemistry - A European Journal |
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Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2012
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Subjects: | |
Online Access: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/synthesis-of-the-originally-proposed-structure-of-palmerolide-c(2745efac-14f6-4fb9-981b-503882ff727f).html https://doi.org/10.1002/chem.201203067 |
Summary: | A stereoselective synthesis of the proposed structure of palmerolide C (2), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum adareanum, utilizes a convergent carbonyl-based coupling strategy to construct the C1-C24 carbon skeleton. Compound 2 was shown to be a diastereomer of palmerolide C, and the structural revision of the natural product is proposed. |
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