Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon.
We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were o...
Published in: | Genetica |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2008
|
Subjects: | |
Online Access: | https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html https://doi.org/10.1007/s10709-008-9240-3 http://www.scopus.com/inward/record.url?scp=51749125047&partnerID=8YFLogxK |
id |
ftunstandrewcris:oai:research-portal.st-andrews.ac.uk:publications/b312ba28-6589-47c8-be26-05f7bc44d003 |
---|---|
record_format |
openpolar |
spelling |
ftunstandrewcris:oai:research-portal.st-andrews.ac.uk:publications/b312ba28-6589-47c8-be26-05f7bc44d003 2024-06-23T07:51:12+00:00 Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. Johnston, Ian Alistair Johnston, I A 2008-11 https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html https://doi.org/10.1007/s10709-008-9240-3 http://www.scopus.com/inward/record.url?scp=51749125047&partnerID=8YFLogxK eng eng https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html info:eu-repo/semantics/restrictedAccess Johnston , I A & Johnston , I A 2008 , ' Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. ' , Genetica , vol. 134 , pp. 325-334 . https://doi.org/10.1007/s10709-008-9240-3 adaptive evolution collagen cross-links lysyl oxidase positive selection Salmo salar AMINO-ACID SITES DROSOPHILA-MELANOGASTER DNA POLYMORPHISM EVOLUTION POPULATIONS NEUTRALITY MUSCLE GROWTH SALAR article 2008 ftunstandrewcris https://doi.org/10.1007/s10709-008-9240-3 2024-06-13T00:22:24Z We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were observed per individual, probably as a consequence of the tetraploid origin of the salmonid genome. We found high polymorphism in the LOX locus (16 alleles expressed in total and several low frequency private alleles) in two natural Atlantic salmon populations and extremely reduced diversity in a farmed population (3 alleles) with low density of collagen crosslinks. We also assessed the relative role of selection in maintaining LOX genetic variability in Atlantic salmon. Results from several neutrality tests suggest that selection is playing a role in shaping diversity at the LOX locus. Positive selection was inferred by three different likelihood phylogeny-based methods and one selected site, identified by all three different methods (PAML, FEL and REL) was located within the "copper-talon" characteristic of LOX proteins. We suggest that the retention of four alleles in the salmon LOX locus could be related to its multiple functions. Article in Journal/Newspaper Atlantic salmon Salmo salar University of St Andrews: Research Portal Talon ENVELOPE(148.658,148.658,59.762,59.762) Genetica 134 3 325 334 |
institution |
Open Polar |
collection |
University of St Andrews: Research Portal |
op_collection_id |
ftunstandrewcris |
language |
English |
topic |
adaptive evolution collagen cross-links lysyl oxidase positive selection Salmo salar AMINO-ACID SITES DROSOPHILA-MELANOGASTER DNA POLYMORPHISM EVOLUTION POPULATIONS NEUTRALITY MUSCLE GROWTH SALAR |
spellingShingle |
adaptive evolution collagen cross-links lysyl oxidase positive selection Salmo salar AMINO-ACID SITES DROSOPHILA-MELANOGASTER DNA POLYMORPHISM EVOLUTION POPULATIONS NEUTRALITY MUSCLE GROWTH SALAR Johnston, Ian Alistair Johnston, I A Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
topic_facet |
adaptive evolution collagen cross-links lysyl oxidase positive selection Salmo salar AMINO-ACID SITES DROSOPHILA-MELANOGASTER DNA POLYMORPHISM EVOLUTION POPULATIONS NEUTRALITY MUSCLE GROWTH SALAR |
description |
We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were observed per individual, probably as a consequence of the tetraploid origin of the salmonid genome. We found high polymorphism in the LOX locus (16 alleles expressed in total and several low frequency private alleles) in two natural Atlantic salmon populations and extremely reduced diversity in a farmed population (3 alleles) with low density of collagen crosslinks. We also assessed the relative role of selection in maintaining LOX genetic variability in Atlantic salmon. Results from several neutrality tests suggest that selection is playing a role in shaping diversity at the LOX locus. Positive selection was inferred by three different likelihood phylogeny-based methods and one selected site, identified by all three different methods (PAML, FEL and REL) was located within the "copper-talon" characteristic of LOX proteins. We suggest that the retention of four alleles in the salmon LOX locus could be related to its multiple functions. |
format |
Article in Journal/Newspaper |
author |
Johnston, Ian Alistair Johnston, I A |
author_facet |
Johnston, Ian Alistair Johnston, I A |
author_sort |
Johnston, Ian Alistair |
title |
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
title_short |
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
title_full |
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
title_fullStr |
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
title_full_unstemmed |
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. |
title_sort |
effect of natural selection on the duplicated lysyl oxidase gene in atlantic salmon. |
publishDate |
2008 |
url |
https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html https://doi.org/10.1007/s10709-008-9240-3 http://www.scopus.com/inward/record.url?scp=51749125047&partnerID=8YFLogxK |
long_lat |
ENVELOPE(148.658,148.658,59.762,59.762) |
geographic |
Talon |
geographic_facet |
Talon |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Johnston , I A & Johnston , I A 2008 , ' Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon. ' , Genetica , vol. 134 , pp. 325-334 . https://doi.org/10.1007/s10709-008-9240-3 |
op_relation |
https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1007/s10709-008-9240-3 |
container_title |
Genetica |
container_volume |
134 |
container_issue |
3 |
container_start_page |
325 |
op_container_end_page |
334 |
_version_ |
1802642219940708352 |