Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon.

We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were o...

Full description

Bibliographic Details
Published in:Genetica
Main Authors: Johnston, Ian Alistair, Johnston, I A
Format: Article in Journal/Newspaper
Language:English
Published: 2008
Subjects:
adaptive evolution
collagen cross-links
lysyl oxidase
positive selection
Salmo salar
AMINO-ACID SITES
DROSOPHILA-MELANOGASTER
DNA POLYMORPHISM
EVOLUTION
POPULATIONS
NEUTRALITY
MUSCLE
GROWTH
SALAR
Talon
Atlantic salmon
Online Access:https://research-portal.st-andrews.ac.uk/en/researchoutput/effect-of-natural-selection-on-the-duplicated-lysyl-oxidase-gene-in-atlantic-salmon(b312ba28-6589-47c8-be26-05f7bc44d003).html
https://doi.org/10.1007/s10709-008-9240-3
http://www.scopus.com/inward/record.url?scp=51749125047&partnerID=8YFLogxK
Description
Summary:We examined the polymorphism of the lysyl oxidase (LOX) locus, involved in the initiation of muscle collagen cross-linking, in three populations of Atlantic salmon with different life histories and growth rates and compared it with a closely related species (rainbow trout). Up to four alleles were observed per individual, probably as a consequence of the tetraploid origin of the salmonid genome. We found high polymorphism in the LOX locus (16 alleles expressed in total and several low frequency private alleles) in two natural Atlantic salmon populations and extremely reduced diversity in a farmed population (3 alleles) with low density of collagen crosslinks. We also assessed the relative role of selection in maintaining LOX genetic variability in Atlantic salmon. Results from several neutrality tests suggest that selection is playing a role in shaping diversity at the LOX locus. Positive selection was inferred by three different likelihood phylogeny-based methods and one selected site, identified by all three different methods (PAML, FEL and REL) was located within the "copper-talon" characteristic of LOX proteins. We suggest that the retention of four alleles in the salmon LOX locus could be related to its multiple functions.

Similar Items