Single freeze per vein strategy with the second-generation cryoballoon for atrial fibrillation: a propensity score-matched study between 180- and 240-s application time in a large cohort of patients

• Main Authors: De Regibus, Valentina, Abugattas, Juan-Pablo, Iacopino, Saverio, Mugnai, Giacomo, Storti, Cesare, Conte, Giulio, Auricchio, Angelo, Ströker, Erwin, Coutiño, Hugo-Enrique, Takarada, Ken, Salghetti, Francesca, Lusoc, Ian, Capulzini, Lucio, Brugada, Pedro, de Asmundis, Carlo, Chierchia, Gian-Battista
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press 2018
• Subjects: Cardiocentro Ticino; 610 Medicine & health; Arctic
• Online Access: https://www.zora.uzh.ch/id/eprint/145189/; https://www.zora.uzh.ch/id/eprint/145189/1/eux279.pdf; https://doi.org/10.5167/uzh-145189; https://doi.org/10.1093/europace/eux279

Aims: The single-freeze strategy using the second-generation cryoballoon (CB-A, Arctic Front Advance, Medtronic, Minneapolis, MN, USA) has been reported to be as effective as the recommended double-freeze approach in several single-centre studies. In this retrospective, international, multicentre study, we compare the 3-min single-freeze strategy with the 4-min single-freeze strategy. Methods and results: Four hundred and thirty-two patients having undergone pulmonary vein isolation (PVI) by means of CB-A using a single-freeze strategy were considered for this analysis. A cohort of patients who were treated with a 3-min strategy (Group 1) was compared with a propensity score-matched cohort of patients who underwent a 4-min strategy (Group 2). Pulmonary vein isolation was successfully achieved in all the veins using the 28-mm CB-A. The procedural and fluoroscopy times were lower in Group 1 (67.8 ± 17 vs. 73.8 ± 26.3, P < 0.05; 14.9 ± 7.8 vs. 24.2 ± 10.6 min, P < 0.05). The most frequent complication was PNP, with no difference between the two groups (P = 0.67). After a mean follow-up of 13 ± 8 months, taking into consideration a blanking period of 3 months, 85.6% of patients in Group 1 and 87% of patients in Group 2 were free from arrhythmia recurrence at final follow-up (P = 0.67). Conclusion: There is no difference in acute success, rate of complications, and freedom from atrial fibrillation recurrences during the follow-up between 3-min and 4-min per vein freeze strategies. The procedural and fluoroscopy times were significantly shorter in 3-min per vein strategy.