Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring

Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering >75%...

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Bibliographic Details
Main Authors: Hubert, Casey R. J., Acosta, Nicole, Waddell, Barbara J., Hasing, Maria E., Qiu, Yuanyuan, Fuzzen, Meghan, Harper, Nathanael B. J., Bautista, María A., Gao, Tiejun, Papparis, Chloe, Doorn, Jean V., Du, Kristine, Xiang, Kevin, Chan, Leslie, Vivas, Laura, Pradhan, Puja, McCalder, Janine, Low, Kashtin, England, Whitney E., Kuzma, Darina, Conly, John, Ryan, M. Cathryn, Achari, Gopal, Hu, Jia, Cabaj, Jason L., Sikora, Chris, Svenson, Larry, Zelyas, Nathan, Servos, Mark. R., Meddings, Jon, Hrudey, Steve E., Frankowski, Kevin, Parkins, Michael D., Pang, Xiaoli, Lee, Bonita E.
Format: Report
Language:English
Published: medRxiv 2022
Subjects:
SARS-CoV-2 Omicron variant
wastewater monitoring
Canada
Fort McMurray
Online Access:http://hdl.handle.net/10012/18384
https://doi.org/10.1101/2022.03.07.22272055
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Summary:Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering >75% of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100% of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants. Alberta Health

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