SNP array dataset for genome-wide association study of causal mutations of thyroid follicular cell carcinoma in dogs
Familial thyroid cancer originating from follicular cells accounts for 5-15% of all the thyroid carcinoma cases in humans. Previously, we described thyroid follicular cell carcinomas in a large number of the Dutch German longhaired pointers (GLPs) with likely an autosomal recessive inheritance patte...
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| Format: | Other/Unknown Material |
| Language: | unknown |
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Wageningen University & Research
2021
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| Online Access: | https://research.wur.nl/en/datasets/snp-array-dataset-for-genome-wide-association-study-of-causal-mut |
| Summary: | Familial thyroid cancer originating from follicular cells accounts for 5-15% of all the thyroid carcinoma cases in humans. Previously, we described thyroid follicular cell carcinomas in a large number of the Dutch German longhaired pointers (GLPs) with likely an autosomal recessive inheritance pattern. Here, we investigated the genetic causes of the disease using a combined approach of genome-wide association study, selective sweep analysis, and ROH analysis based on 170k SNP array genotype data. A region 0-5 Mb on chromosome 17 harboring the TPO gene was identified to be associated with the disease. |
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