Determination of perfluorinated alkyl acid concnetrations in biological standard reference materials

Standard reference materials (SRMs) are homogeneous, well-characterized materials used to validate measurements and improve the quality of analytical data. The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have mass fraction values assigned for legacy pollutants...

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Bibliographic Details
Published in:Analytical and Bioanalytical Chemistry
Main Authors: Reiner, J.L., O'Connell, S.G., Butt, C.M., Kwadijk, C.J.A.F.
Format: Article in Journal/Newspaper
Language:English
Published: 2012
Subjects:
environment
great-lakes
human plasma
marine food-web
matrices
perfluoroalkyl contaminants
perfluorooctane sulfonate
samples
serum
water
Beluga
Beluga whale
Beluga*
Sperm whale
Online Access:https://research.wur.nl/en/publications/determination-of-perfluorinated-alkyl-acid-concnetrations-in-biol
https://doi.org/10.1007/s00216-012-5943-5
Description
Summary:Standard reference materials (SRMs) are homogeneous, well-characterized materials used to validate measurements and improve the quality of analytical data. The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have mass fraction values assigned for legacy pollutants. These SRMs can also serve as test materials for method development, method validation, and measurement for contaminants of emerging concern. Because inter-laboratory comparison studies have revealed substantial variability of measurements of perfluoroalkyl acids (PFAAs), future analytical measurements will benefit from determination of consensus values for PFAAs in SRMs to provide a means to demonstrate method-specific performance. To that end, NIST, in collaboration with other groups, has been measuring concentrations of PFAAs in a variety of SRMs. Here we report levels of PFAAs and perfluorooctane sulfonamide (PFOSA) determined in four biological SRMs: fish tissue (SRM 1946 Lake Superior Fish Tissue, SRM 1947 Lake Michigan Fish Tissue), bovine liver (SRM 1577c), and mussel tissue (SRM 2974a). We also report concentrations for three in-house quality-control materials: beluga whale liver, pygmy sperm whale liver, and white-sided dolphin liver. Measurements in SRMs show an array of PFAAs, with perfluorooctane sulfonate (PFOS) being the most frequently detected. Reference and information values are reported for PFAAs measured in these biological SRMs.

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