Resistance of common carp (Cyprinus carpio L.) to Cyprinid herpesvirus-3 is influenced by major histocompatibility (MH) class II B gene polymorphism

The role of MH class II B (Cyca-DAB1-like) genes in resistance of common carp (Cyprinus carpio L) to Cyprinid herpesvirus-3 (CyHV-3), also known as koi herpesvirus (KHV) was analysed. The material consisted of 934 fish from six carp crosses. Fish were challenged with CyHV-3 at an age of 7 and 10 mon...

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Bibliographic Details
Published in:Fish & Shellfish Immunology
Main Authors: Rakus, K.L., Wiegertjes, G.F., Adamek, M., Siwicki, A.K., Lepa, A., Irnazarow, I.
Format: Article in Journal/Newspaper
Language:English
Published: 2009
Subjects:
aeromonas-salmonicida
atlantic salmon
cd4(+) t-cells
complex loci
disease resistance
frequency-dependent selection
gill necrosis virus
interstitial nephritis
koi herpesvirus
salmon salmo-salar
Atlantic salmon
Salmo salar
Online Access:https://research.wur.nl/en/publications/resistance-of-common-carp-cyprinus-carpio-l-to-cyprinid-herpesvir
https://doi.org/10.1016/j.fsi.2009.03.001
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Summary:The role of MH class II B (Cyca-DAB1-like) genes in resistance of common carp (Cyprinus carpio L) to Cyprinid herpesvirus-3 (CyHV-3), also known as koi herpesvirus (KHV) was analysed. The material consisted of 934 fish from six carp crosses. Fish were challenged with CyHV-3 at an age of 7 and 10 months. During challenge experiments the peak of mortality caused by CyHV-3 was observed at days 8-12 p.i. and the overall cumulative mortality reached 79.9%. Among six Cyca-DAB1-like genotypes, revealed by PCR-RF-SSCP analysis, one genotype (E) was found associated with higher resistance to CyHV-3. Three other genotypes (B, H and J) could be linked to higher susceptibility to CyHV-3. Analysis of the alleles that compose the Cyca-DAB1-like genotypes linked one particular allele (Cyca-DAB1*05) to significantly increased, and two alleles (Cyca-DAB1*02 and Cyca-DAB1*06) to significantly decreased resistance to CyHV-3. Our data indicate that MH class II B genes could be used as potential genetic markers in breeding of common carp for resistance to this virus.

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