Synthesis and characterization of a lipase-friendly DES based on cholinium dihydrogen phosphate

The main objective of the present work was to synthesize and characterize three novel lipase-friendly deep eutectic solvents (DESs) using cholinium dihydrogen phosphate (N1112OHDHP) as hydrogen bond acceptor and ethylene glycol (EG) and/or glycerol (GL) as hydrogen bond donors in the following propo...

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Bibliographic Details
Published in:Journal of Molecular Liquids
Main Authors: Álvarez Álvarez, María Salomé, Longo González, María Asunción, Deive Herva, Francisco Javier, Rodríguez Rodríguez, Ana María
Format: Article in Journal/Newspaper
Language:English
Published: Journal of Molecular Liquids 2021
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Online Access:http://hdl.handle.net/11093/2970
https://doi.org/10.1016/j.molliq.2021.117230
https://linkinghub.elsevier.com/retrieve/pii/S0167732221019541
Description
Summary:The main objective of the present work was to synthesize and characterize three novel lipase-friendly deep eutectic solvents (DESs) using cholinium dihydrogen phosphate (N1112OHDHP) as hydrogen bond acceptor and ethylene glycol (EG) and/or glycerol (GL) as hydrogen bond donors in the following proportions: N1112OHDHP:EG (molar ratio 1:2), N1112OHDHP:GL (molar ratio 1:2) and N1112OHDHP:EG:GL (molar ratio 1:1:1). FTIR, 1H NMR, TGA and DSC were employed to shed light on their distinctive structural characteristics. Density, refractive index and dynamic viscosity were also measured at different temperatures, and the experimental data were correlated with several well-known equations. Finally, the suitability of the newly synthesized DESs to be employed in biocatalytic reactions was demonstrated by analysing the activity of a commercial enzyme (Candida antarctica lipase B) after being in contact with them. Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG Agencia Estatal de Investigación | Ref. RTI2018-094702-B-I00 Xunta de Galicia | Ref. ED481D-2019/017