Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting mic...

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Bibliographic Details
Published in:Biological Psychiatry
Main Authors: Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep, TOSATO, Sarah
Other Authors: Riff Jensen, Lar, Werge, Thoma, Karagiannidis, Iordani, Tosato, Sarah, Ingason, Andre
Format: Article in Journal/Newspaper
Language:English
Published: 2016
Subjects:
AADAC
Association study
CNV
Copy number variation
Gilles de la Tourette syndrome
Neuropsychiatric disorder
Adult
Animal
Attention Deficit Disorder with Hyperactivity
Cohort Studie
Comorbidity
DNA Copy Number Variation
Denmark
Exon
Female
Genotyping Technique
Germany
Human
Hungary
Iceland
Italy
Male
Mice
Netherland
Sequence Deletion
Tourette Syndrome
Online Access:http://hdl.handle.net/11562/950317
https://doi.org/10.1016/j.biopsych.2015.08.027
http://www.biologicalpsychiatryjournal.com/article/S0006-3223(15)00726-X/abstract
Description
Summary:Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations.

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