| Summary: | The papers of this thesis are not available in Munin: 1. Marit Nøst Hegseth, Lionel Camus, Lisa Bjørnsdatter Helgason, Raffaella Bocchetti, Geir Wing Gabrielsen and Francesco Regoli: 'Hepatic antioxidant responses related to levels of PCBs and metals in chicks of three Arctic seabird species', Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2011) 154: 28-35. Available at http://dx.doi.org/10.1016/j.cbpc.2011.02.008 2. Marit Nøst Hegseth, Lionel Camus, Stefania Gorbi, Francesco Regoli and Geir Wing Gabrielsen: 'Effects of exposure to halogenated organic compounds combined with dietary restrictions on the antioxidant defense system in herring gull chicks', Science of the Total Environment (2011) 409 (14):2717-24. Available at http://dx.doi.org/10.1016/j.scitotenv.2011.04.004 3. Marta K. Jansen, Marit Nøst Hegseth, Raffaella Bocchetti, Francesco Regoli, Geir W. Gabrielsen and Lionel Camus: 'Impact of Halogenated Organic Contaminant Exposure and Fasting on Antioxidant Defence System on the Kidney of Herring Gull Chicks' (manuscript) 4. Marit Nøst Hegseth, Francesco Regoli, Stefania Gorbi, Raffaella Bocchetti, Geir Wing Gabrielsen and Lionel Camus: 'Lysosomal and lipid-associated parameters in the livers of three species of arctic seabird chicks : Species differences and relationships with contaminant levels', Marine Pollution Bulletin (2011) 62(8): 1652-60. Available at http://dx.doi.org/10.1016/j.marpolbul.2011.06.011 5. Marit Nøst Hegseth, Stephania Gorbi, Raffaella Bocchetti, Geir Wing Gabrielsen, Francesco Regoli and Lionel Camus: 'Effects of contaminant exposure and food restriction on hepatic lysosomal and lipid associated parameters in Herring gull chicks' (submitted manuscript to Environmental Research) This PhD study has investigated how two commonly occurring environmental stress factors in the Arctic (periods with little food and exposure to halogenated organic contaminants) have had an impact on two important cellular defense mechanisms in Arctic seabirds. The antioxidant defense system and autophagic lysosomal responses in liver cells of Arctic seabird chicks have been studied. Samples were collected from three seabird species at Svalbard and Tromsø area: Black-legged kittiwake (Rissa tridactyla), northern fulmar (Fulmarus glacialis) and herring gull (Larus argentatus ), as well as samples from a feeding experiment with herring gull chicks. The findings show that there are major species differences, and that the antioxidant defense system and autophagic lysosomal responses in the seabird chicks are affected by factors such as diet, species-specific physiology and fasting, as well as high-grade contaminant exposure. Some of the effects of contaminant exposure were dose-dependent. The contaminant concentrations found in the birds in this study were relatively low. Hence, more pronounced effects could therefore be present in wild-living birds that have higher contaminant concentrations than birds in this study. Some of the cellular effects observed in this study have been associated with adverse health effects in other animal species. Additional studies of these cellular systems in seabirds are recommended in order to implement such analysis in regularly monitoring of seabird health status in the future and may contribute to improved management of the important seabird populations in these areas.
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