Pharmacokinetics of a long-acting subcutaneous eprinomectin injection in semi-domesticated reindeer (Rangifer tarandus tarandus) - a pilot study

• Published in: Environmental Toxicology and Pharmacology
• Main Authors: Davidson, Rebecca K., Fæste, Christiane Kruse, Uhlig, Silvio, Tukun, Feng-Ling, Lian, Hans Edvin, Solvang, Hans Arne, Thorvaldsen, Renate, Folkow, Lars, Sanchez Romano, Javier, Kilvær, Marianne V., Holmgren, Karin Elisabeth, Nymo, Ingebjørg Helena
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2022
• Subjects: Rangifer; Rangifer tarandus
• Online Access: https://hdl.handle.net/10037/28091; https://doi.org/10.1016/j.etap.2022.104041

Reindeer (Rangifer tarandus tarandus) are exposed to the pathogenic parasitic nematode Elaphostrongylus rangiferi during grazing. The severity of disease is dose-dependent. Prophylactic anthelmintic treatment is needed to improve animal health and reindeer herding sustainability. Herds are traditionally only gathered once during the summer, requiring a drug with a persistent effect. In this study we investigated the suitability of long-acting eprinomectin, given as a single subcutaneous injection at 1mg/kg bodyweight in adult reindeer and calves. Plasma and faeces concentrations were determined using ultra-high performance liquid chromatography high resolution mass spectrometry (UHPLC-HRMS). Plasma concentrations remained above the presumed effect level of 2ng/mL for 80 days, demonstrating the drug's potential. Pharmacokinetic parameters were compared to other species using allometric scaling. Calves and adults had slightly different profiles. No viable faecal nematode eggs were detected during treatment. Eprinomectin was measurable in the reindeer faeces up to 100 days, which is of environmental concern.