Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana

• Published in: Natural Product Research
• Main Authors: Michael Siranjeevi, Raja Priyanka Mary, Hansen, Espen, Isaksson, Johan, Andersen, Jeanette hammer, Østnes Hansen, Kine
• Format: Article in Journal/Newspaper
• Language: English
• Published: Taylor & Francis 2019
• Subjects: VDP::Medical disciplines: 700::Basic medical; dental and veterinary science disciplines: 710::Pharmacology: 728; VDP::Medisinske Fag: 700::Basale medisinske; odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728; VDP::Mathematics and natural science: 400::Basic biosciences: 470::Molecular biology: 473; VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473; Arctic
• Online Access: https://hdl.handle.net/10037/16904; https://doi.org/10.1080/14786419.2019.1574788

This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 20 February 2019, available online: https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1574788 . The new guanidine alkaloid Dendrobeaniamine A (1) was isolated from the organic extract of the Arctic marine bryozoan Dendrobeania murrayana . The chemical structure of 1 was elucidated by spectroscopic experiments, including 1D and 2D NMR and HRESIMS analysis. Compound 1 is a lipoamino acid, consisting of a C 12 fatty acid anchored to the amino acid arginine. The bioactivity of 1 was evaluated using cellular and biochemical assays, but the compound did not show cytotoxic, antimicrobial, anti-inflammatory or antioxidant activities