Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

Source at https://doi.org/10.1111/jth.14539. Background - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation...

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Bibliographic Details
Published in:Journal of Thrombosis and Haemostasis
Main Authors: Liang, Robin Amanda, Høiland, Ina Isabella, Ueland, Thor, Aukrust, Pål, Snir, Omri, Hindberg, Kristian, Brækkan, Sigrid Kufaas, Garred, Peter, Mollnes, Tom Eirik, Hansen, John-Bjarne
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2019
Subjects:
complement
deep vein thrombosis
mannose‐binding lectin
pulmonary embolism
venous thromboembolism
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775
Tromsø
Online Access:https://hdl.handle.net/10037/16191
https://doi.org/10.1111/jth.14539
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Summary:Source at https://doi.org/10.1111/jth.14539. Background - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives - To investigate the association between plasma MBL levels and future risk of incident VTE. Methods - We conducted a nested case‐control study in 417 VTE patients and 849 age‐matched and sex‐matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme‐linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results - Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56‐1.10) and for DVT (OR 0.70, 95% CI: 0.47‐1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions - Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.

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