Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population
The papers I & II are not available in Munin. Paper I: Schei, J., Stefansson, V.T.N., Mathisen, U.D., Eriksen, B.O., Solbu, M.D., Jenssen, T.G. & Melsom, T. (2016). Residual Associations of Inflammatory Markers with eGFR after Accounting for Measured GFR in a Community-Based Cohort without C...
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UiT The Arctic University of Norway
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ftunivtroemsoe:oai:munin.uit.no:10037/12838 2023-05-15T18:34:43+02:00 Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population The Renal Iohexol Clearance Survey Follow-Up Study Schei, Jørgen 2018-06-08 https://hdl.handle.net/10037/12838 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet https://hdl.handle.net/10037/12838 openAccess Copyright 2018 The Author(s) VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2018 ftunivtroemsoe 2021-06-25T17:55:58Z The papers I & II are not available in Munin. Paper I: Schei, J., Stefansson, V.T.N., Mathisen, U.D., Eriksen, B.O., Solbu, M.D., Jenssen, T.G. & Melsom, T. (2016). Residual Associations of Inflammatory Markers with eGFR after Accounting for Measured GFR in a Community-Based Cohort without CKD. Available in Clinical journal of the American Society of Nephrology, 11(2), 280-286. Paper II: Schei, J., Stefansson, V.T.N., Eriksen, B.O., Jenssen, T.G., Solbu, M.D., Wilsgaard, T. & Melsom, T. (2017). Association of TNF receptor 2 and CRP with GFR Decline in the General Nondiabetic Population. Available in Clinical journal of the American Society of Nephrology, 12(4), 624-634. The prevalence of chronic kidney disease (CKD) increases rapidly with age, affecting more than one-third of people over 70 years old. The age-related glomerular filtration rate (GFR) decline is an important risk factor for CKD and kidney failure. Identifying novel risk factors for early kidney disease, manifested as accelerated GFR decline or low-grade albuminuria, may suggest underlying pathologic mechanisms for the development of CKD and prompt the opportunity for early-targeted treatment. Low-grade inflammation and oxidative stress are linked to aging and CKD. In particular, TNF receptors and urinary markers of oxidatively damaged nucleic acids have predicted GFR decline and albuminuria in people with diabetes. However, whether these biomarkers predict an accelerated GFR decline or albuminuria in the general population without CKD and diabetes remains unclear. The few previous studies from the general population are limited by the use of estimated GFR (eGFR), which is inaccurate and may be biased by non-GFR-related factors. In the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), we measured the GFR (mGFR) in 1627 middle-aged people without cardiovascular disease, diabetes, or kidney disease. After a median follow-up of 5.6 years, 1324 participants underwent the same GFR measurements in the RENIS Follow-Up (RENIS-FU) study. In cross-sectional analyses from RENIS-T6, we found that the eGFR values based on creatinine and cystatin C were associated with inflammatory biomarkers independent of mGFR, indicating a non-GFR-related influence of inflammation on eGFR. In longitudinal analyses, we found that a higher baseline serum level of high-sensitivity C-reactive protein, but not of TNF receptor 2, was associated with an accelerated age-related mGFR decline and an increased risk of incident CKD. Markers of oxidative stress, measured as the urinary excretion of oxidatively damaged DNA and RNA (8-oxodG and 8-oxoGuo), were not significantly associated with the age-related mGFR decline, but higher urinary excretion of 8-oxoGuo predicted low-grade albuminuria at follow-up. Studies with an even longer observation period, multiple biomarkers, and repeated GFR measurements are needed to fully evaluate the effects of low-grade inflammation and oxidative stress on age-related GFR decline in the general population. Doctoral or Postdoctoral Thesis Tromsø University of Tromsø: Munin Open Research Archive Melsom ENVELOPE(-46.183,-46.183,-60.500,-60.500) Solbu ENVELOPE(8.680,8.680,63.377,63.377) Stefansson ENVELOPE(-62.417,-62.417,-69.467,-69.467) Tromsø |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Schei, Jørgen Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
description |
The papers I & II are not available in Munin. Paper I: Schei, J., Stefansson, V.T.N., Mathisen, U.D., Eriksen, B.O., Solbu, M.D., Jenssen, T.G. & Melsom, T. (2016). Residual Associations of Inflammatory Markers with eGFR after Accounting for Measured GFR in a Community-Based Cohort without CKD. Available in Clinical journal of the American Society of Nephrology, 11(2), 280-286. Paper II: Schei, J., Stefansson, V.T.N., Eriksen, B.O., Jenssen, T.G., Solbu, M.D., Wilsgaard, T. & Melsom, T. (2017). Association of TNF receptor 2 and CRP with GFR Decline in the General Nondiabetic Population. Available in Clinical journal of the American Society of Nephrology, 12(4), 624-634. The prevalence of chronic kidney disease (CKD) increases rapidly with age, affecting more than one-third of people over 70 years old. The age-related glomerular filtration rate (GFR) decline is an important risk factor for CKD and kidney failure. Identifying novel risk factors for early kidney disease, manifested as accelerated GFR decline or low-grade albuminuria, may suggest underlying pathologic mechanisms for the development of CKD and prompt the opportunity for early-targeted treatment. Low-grade inflammation and oxidative stress are linked to aging and CKD. In particular, TNF receptors and urinary markers of oxidatively damaged nucleic acids have predicted GFR decline and albuminuria in people with diabetes. However, whether these biomarkers predict an accelerated GFR decline or albuminuria in the general population without CKD and diabetes remains unclear. The few previous studies from the general population are limited by the use of estimated GFR (eGFR), which is inaccurate and may be biased by non-GFR-related factors. In the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), we measured the GFR (mGFR) in 1627 middle-aged people without cardiovascular disease, diabetes, or kidney disease. After a median follow-up of 5.6 years, 1324 participants underwent the same GFR measurements in the RENIS Follow-Up (RENIS-FU) study. In cross-sectional analyses from RENIS-T6, we found that the eGFR values based on creatinine and cystatin C were associated with inflammatory biomarkers independent of mGFR, indicating a non-GFR-related influence of inflammation on eGFR. In longitudinal analyses, we found that a higher baseline serum level of high-sensitivity C-reactive protein, but not of TNF receptor 2, was associated with an accelerated age-related mGFR decline and an increased risk of incident CKD. Markers of oxidative stress, measured as the urinary excretion of oxidatively damaged DNA and RNA (8-oxodG and 8-oxoGuo), were not significantly associated with the age-related mGFR decline, but higher urinary excretion of 8-oxoGuo predicted low-grade albuminuria at follow-up. Studies with an even longer observation period, multiple biomarkers, and repeated GFR measurements are needed to fully evaluate the effects of low-grade inflammation and oxidative stress on age-related GFR decline in the general population. |
format |
Doctoral or Postdoctoral Thesis |
author |
Schei, Jørgen |
author_facet |
Schei, Jørgen |
author_sort |
Schei, Jørgen |
title |
Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
title_short |
Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
title_full |
Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
title_fullStr |
Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
title_full_unstemmed |
Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population |
title_sort |
oxidative stress and inflammation as risk factors for accelerated age-related gfr decline and albuminuria in the general population |
publisher |
UiT The Arctic University of Norway |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/12838 |
long_lat |
ENVELOPE(-46.183,-46.183,-60.500,-60.500) ENVELOPE(8.680,8.680,63.377,63.377) ENVELOPE(-62.417,-62.417,-69.467,-69.467) |
geographic |
Melsom Solbu Stefansson Tromsø |
geographic_facet |
Melsom Solbu Stefansson Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/12838 |
op_rights |
openAccess Copyright 2018 The Author(s) |
_version_ |
1766219600313188352 |