Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population

• Main Author: Schei, Jørgen
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: UiT The Arctic University of Norway 2018
• Subjects: VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi; urologi: 772; VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology; urology: 772; The Tromsø Study; Tromsøundersøkelsen; Melsom; Solbu; Stefansson; Tromsø
• Online Access: https://hdl.handle.net/10037/12838

The papers I & II are not available in Munin. Paper I: Schei, J., Stefansson, V.T.N., Mathisen, U.D., Eriksen, B.O., Solbu, M.D., Jenssen, T.G. & Melsom, T. (2016). Residual Associations of Inflammatory Markers with eGFR after Accounting for Measured GFR in a Community-Based Cohort without CKD. Available in Clinical journal of the American Society of Nephrology, 11(2), 280-286. Paper II: Schei, J., Stefansson, V.T.N., Eriksen, B.O., Jenssen, T.G., Solbu, M.D., Wilsgaard, T. & Melsom, T. (2017). Association of TNF receptor 2 and CRP with GFR Decline in the General Nondiabetic Population. Available in Clinical journal of the American Society of Nephrology, 12(4), 624-634. The prevalence of chronic kidney disease (CKD) increases rapidly with age, affecting more than one-third of people over 70 years old. The age-related glomerular filtration rate (GFR) decline is an important risk factor for CKD and kidney failure. Identifying novel risk factors for early kidney disease, manifested as accelerated GFR decline or low-grade albuminuria, may suggest underlying pathologic mechanisms for the development of CKD and prompt the opportunity for early-targeted treatment. Low-grade inflammation and oxidative stress are linked to aging and CKD. In particular, TNF receptors and urinary markers of oxidatively damaged nucleic acids have predicted GFR decline and albuminuria in people with diabetes. However, whether these biomarkers predict an accelerated GFR decline or albuminuria in the general population without CKD and diabetes remains unclear. The few previous studies from the general population are limited by the use of estimated GFR (eGFR), which is inaccurate and may be biased by non-GFR-related factors. In the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), we measured the GFR (mGFR) in 1627 middle-aged people without cardiovascular disease, diabetes, or kidney disease. After a median follow-up of 5.6 years, 1324 participants underwent the same GFR measurements in the RENIS Follow-Up (RENIS-FU) study. ...