Biomarkers of the cholinergic and dopaminergic signaling pathways in Arctic beluga whales (Delphinapterus leucas): Relationship to methylmercury and selenium
There are increasing concerns about potential neurotoxicity of chronic methylmercury (MeHg) exposure in Arctic wildlife and human populations. The relationships between mercury (Hg), MeHg, inorganic Hg (iHg) and selenium (Se) exposure, and neurochemical and molecular biomarkers in beluga whales (Del...
| Main Authors: | , |
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| Format: | Article in Journal/Newspaper |
| Language: | unknown |
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NRC Research Press (a division of Canadian Science Publishing)
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/87454 http://www.nrcresearchpress.com/doi/abs/10.1139/AS-2017-0033 |
| Summary: | There are increasing concerns about potential neurotoxicity of chronic methylmercury (MeHg) exposure in Arctic wildlife and human populations. The relationships between mercury (Hg), MeHg, inorganic Hg (iHg) and selenium (Se) exposure, and neurochemical and molecular biomarkers in beluga whales (Delphinapterus leucas Pallas, 1776) were characterized. Samples were collected in 2008 (n = 20) and 2010 (n = 15) in the Canadian Arctic from hunter-harvested beluga whales. Total Hg concentrations in the temporal cortex and cerebellum were 21.0 Âą 22.6 mg kg-1 dry weight (dw) and 14.9 Âą 18.9 mg kg-1 dw, respectively. Monoamine oxidase (MAO) activity was predicted by MeHg and the molar ratio of total Hg to Se (Hg:Se, p The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author. |
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