Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study

Abstract Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of t...

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Bibliographic Details
Published in:Arthritis Research & Therapy
Main Authors: Butt, Christopher, Peddle, Lynette, Greenwood, Celia, Hamilton, Sean, Gladman, Dafna, Rahman, Proton
Format: Article in Journal/Newspaper
Language:English
Published: 2006
Subjects:
Canada
Newfoundland
Online Access:http://hdl.handle.net/1807/86394
https://doi.org/10.1186/ar1880
Description
Summary:Abstract Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.

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