Transcriptomic profiling in fins of Atlantic salmon parasitized with sea lice: evidence for an early imbalance between chalimus-induced immunomodulation and the host’s defense response

• Published in: International Journal of Molecular Sciences
• Main Authors: Umasuthan, N, Xue, X, Caballero-Solares, A, Kumar, S, Westcott, JD, Chen, Z, Fast, MD, Skugor, S, Nowak, BF, Taylor, RG, Rise, ML
• Format: Article in Journal/Newspaper
• Language: English
• Published: Molecular Diversity Preservation International 2020
• Subjects: Lepeophtheirus salmonis; chalimus; Salmo salar; fin transcriptome; immunomodulation; anti-sea lice response; 44K microarray; immunogenomics; Atlantic salmon
• Online Access: https://eprints.utas.edu.au/35010/; https://eprints.utas.edu.au/35010/1/140961%20-%20Transcriptomic%20profiling%20in%20fins%20of%20Atlantic%20salmon%20parasitized%20with%20sea%20lice.pdf

Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated the early transcriptomic responses in pelvic fins of Atlantic salmon parasitized with chalimus I stage sea lice. Fin samples collected from non-infected (i.e., pre-infected) control (PRE) and at chalimus-attachment sites (ATT) and adjacent to chalimus-attachment sites (ADJ) from infected fish were used in profiling global gene expression using 44K microarrays. We identified 6568 differentially expressed probes (DEPs, FDR p L. salmonis.