Transcriptomic profiling in fins of Atlantic salmon parasitized with sea lice: evidence for an early imbalance between chalimus-induced immunomodulation and the host’s defense response

Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated the early transcriptomic responses in pelvic fins of Atlantic salmon parasit...

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Bibliographic Details
Published in:International Journal of Molecular Sciences
Main Authors: Umasuthan, N, Xue, X, Caballero-Solares, A, Kumar, S, Westcott, JD, Chen, Z, Fast, MD, Skugor, S, Nowak, BF, Taylor, RG, Rise, ML
Format: Article in Journal/Newspaper
Language:English
Published: Molecular Diversity Preservation International 2020
Subjects:
Lepeophtheirus salmonis
chalimus
Salmo salar
fin transcriptome
immunomodulation
anti-sea lice response
44K microarray
immunogenomics
Atlantic salmon
Online Access:https://eprints.utas.edu.au/35010/
https://eprints.utas.edu.au/35010/1/140961%20-%20Transcriptomic%20profiling%20in%20fins%20of%20Atlantic%20salmon%20parasitized%20with%20sea%20lice.pdf
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Summary:Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated the early transcriptomic responses in pelvic fins of Atlantic salmon parasitized with chalimus I stage sea lice. Fin samples collected from non-infected (i.e., pre-infected) control (PRE) and at chalimus-attachment sites (ATT) and adjacent to chalimus-attachment sites (ADJ) from infected fish were used in profiling global gene expression using 44K microarrays. We identified 6568 differentially expressed probes (DEPs, FDR p L. salmonis.

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