Preliminary success using hydrogen peroxide to treat Atlantic salmon Salmo salar L. affected with experimentally induced amoebic gill disease (AGD)

Currently the only effective and commercially used treatment for amoebic gill disease (AGD) in farmed Tasmanian Atlantic salmon is freshwater bathing. Hydrogen peroxide (H 2 O 2 ), commonly used throughout the aquaculture industry for a range of topical skin and gill infections, was trialled in vitr...

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Bibliographic Details
Published in:Journal of Fish Diseases
Main Authors: Adams, MB, Crosbie, PBB, Nowak, BF
Format: Article in Journal/Newspaper
Language:English
Published: Blackwell Publishing Ltd 2012
Subjects:
Agricultural and Veterinary Sciences
Veterinary Sciences
Veterinary Anaesthesiology and Intensive Care
Atlantic salmon
Salmo salar
Online Access:https://doi.org/10.1111/j.1365-2761.2012.01422.x
http://www.ncbi.nlm.nih.gov/pubmed/22882640
http://ecite.utas.edu.au/78592
Description
Summary:Currently the only effective and commercially used treatment for amoebic gill disease (AGD) in farmed Tasmanian Atlantic salmon is freshwater bathing. Hydrogen peroxide (H 2 O 2 ), commonly used throughout the aquaculture industry for a range of topical skin and gill infections, was trialled in vitro and in vivo to ascertain its potential as an alternative treatment against AGD. Under in vitro conditions, trophozoites of Neoparamoeba perurans were exposed to three concentrations of H 2 O 2 in seawater (500, 1000 & 1500 mg.l -1 ) over four durations (10, 20, 30 & 60 min) each at two temperatures (12 & 18C). Trophozoite viability was assessed immediately post exposure and after 24 hours. A concentration/duration combinationof 1000 mg.l -1 for > 10 min demonstrated potent amoebicidal activity. Subsequently, Atlantic salmon mildly affected with experimentally induced AGD were treated with H 2 O 2 at 12 and 18C for 15 minutes at 1250 mg.l -1 and their re-infection rate compared to freshwater treated fish over 21 days. Significant differences in the percentage of filaments affected with hyperplastic lesions (in association with amoebae) and plasma osmolality were noted between treatment groups immediately post-bath. However, the results were largely equivocal in terms of disease resolution over a three week period following treatment. These data suggest that H 2 O 2 treatment in seawater successfully ameliorated a clinically light case of AGD under laboratory conditions.

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