The effect of levamisole as an adjuvant on the humoral immune response of Atlantic salmon ( Salmo salar L. )

Pre and post-smolt Atlantic salmon (Salmo salar L.) were administered a levamisole adjuvanted Vibrio anguillarum vaccine by bath or intraperitoneal (IP) injection. A significant serum anti-V. anguillarum antibody response was elicited in groups of fish administered an IP injection of bacterium only....

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Bibliographic Details
Main Authors: Morrison, RN, Nowak, BF, Carson, J
Format: Article in Journal/Newspaper
Language:English
Published: European Association of Fish Pathologists 2000
Subjects:
Agricultural and Veterinary Sciences
Fisheries Sciences
Fish Pests and Diseases
Atlantic salmon
Salmo salar
Online Access:http://ecite.utas.edu.au/18447
Description
Summary:Pre and post-smolt Atlantic salmon (Salmo salar L.) were administered a levamisole adjuvanted Vibrio anguillarum vaccine by bath or intraperitoneal (IP) injection. A significant serum anti-V. anguillarum antibody response was elicited in groups of fish administered an IP injection of bacterium only. Fish (pre and post-smolt) treated with the levamisole adjuvanted vaccine (IP and bath) showed a suppressed response relative to the respective positive (vaccinated) control groups. No detectable antibody response was elicited in fish not treated or treated with a placebo. Results from this trial suggest that levamisole as an adjuvant has a narrow range of efficacy.

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