Comparative immunological characterization of type-specific and conserved B-cell epitopes of pinniped, felid and canid herpesviruses.

Murine monoclonal antibodies (MAbs) were generated against phocid herpesviruses (PhHV 2557/Han88 and 7848/Han90) isolated from European harbour seals (Phoca vitulina), and against strains of both felid (FHV strain FVR 605) and canid herpesviruses (CHV isolate 5105/Han89). MAbs were characterized wit...

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Bibliographic Details
Published in:Archives of Virology
Main Authors: Lebich, M., Harder, T.C. (Timm), Frey, H.R., Visser, I.K.G. (Ilona), Osterhaus, A.D.M.E. (Albert), Liess, B.
Format: Article in Journal/Newspaper
Language:English
Published: 1994
Subjects:
0 (Antibodies
Monoclonal)
Viral)
0 (Epitopes)
Alphaherpesvirinae/*immunology/isolation & purification
Animals
Antibodies
Monoclonal/immunology
Viral/immunology
Antibody Specificity
B-Lymphocytes/*immunology
Cats
Cells
Cultured
Comparative Study
Dogs
Epitopes/*immunology
Herpesviridae Infections/microbiology/veterinary
Immunoenzyme Techniques/veterinary
Neutralization Tests
Seals
Support
Non-U.S. Gov't
Swine
Phoca vitulina
Online Access:http://repub.eur.nl/pub/3501
https://doi.org/10.1007/BF01321062
Description
Summary:Murine monoclonal antibodies (MAbs) were generated against phocid herpesviruses (PhHV 2557/Han88 and 7848/Han90) isolated from European harbour seals (Phoca vitulina), and against strains of both felid (FHV strain FVR 605) and canid herpesviruses (CHV isolate 5105/Han89). MAbs were characterized with respect to certain biological properties and used to outline antigenicity profiles of isolates of PhHV (n = 8), FHV (n = 7) and CHV (n = 3) in enzyme immunoassays employing fixed infected ce

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