Antibacterial activity of selected metabolites from Chilean lichen species against methycillin-resistan staphylococci

The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warner...

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Bibliographic Details
Published in:Natural Product Research
Main Authors: Giuseppe Celenza, Bernardetta Segatore, Domenico Setacci, Mariagrazia Perilli, Fabrizia Brisdelli, Pierangelo Bellio, Marisa Piovano, Juan A. Garbarino, Gianfranco Amicosante, NICOLETTI, Marcello
Other Authors: Giuseppe, Celenza, Bernardetta, Segatore, Domenico, Setacci, Mariagrazia, Perilli, Fabrizia, Brisdelli, Pierangelo, Bellio, Marisa, Piovano, Juan A., Garbarino, Gianfranco, Amicosante, Nicoletti, Marcello
Format: Article in Journal/Newspaper
Language:English
Published: TAYLOR & FRANCIS LTD 2013
Subjects:
antimicrobial resistance
methicillin-resistant staphylococci
lichen secondary metabolite
antibacterial activity
Antarc*
Antarctica
Online Access:http://hdl.handle.net/11573/626036
https://doi.org/10.1080/14786419.2012.730043
Description
Summary:The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.

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