Allosteric modulation of monomeric proteins

Multimeric proteins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins (e.g., myoglobin) usually are assumed to be non-allosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors cas...

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Bibliographic Details
Main Authors: ASCENZI, Paolo, BOCEDI, ALESSIO, BOLLI, ALESSANDRO, POLTICELLI, Fabio, FASANO MAURO, NOTARI STEFANIA
Other Authors: Ascenzi, Paolo, Bocedi, Alessio, Bolli, Alessandro, Fasano, Mauro, Notari, Stefania, Polticelli, Fabio
Format: Article in Journal/Newspaper
Language:Italian
English
Published: 2005
Subjects:
Allosteria
proteine monomeriche
mioglobina
trombina
albumina
Sperm whale
Online Access:http://hdl.handle.net/11590/269853
Description
Summary:Multimeric proteins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins (e.g., myoglobin) usually are assumed to be non-allosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human thrombin, generally considered as molecular models of monomeric proteins, are summarized.

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