Allosteric modulation of monomeric proteins RID A-7100-2008 RID A-4573-2009

Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors ca...

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Bibliographic Details
Main Authors: Ascenzi P, Bocedi A, Bolli A, Fasano M, Notari S, POLTICELLI, Fabio
Other Authors: Ascenzi, P, Bocedi, A, Bolli, A, Fasano, M, Notari, S, Polticelli, Fabio
Format: Article in Journal/Newspaper
Language:unknown
Published: 2005
Subjects:
Sperm whale
Online Access:http://hdl.handle.net/11590/120262
Description
Summary:Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.

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