Age and heat stress as determinants of telomere length in a long-lived fish, the Siberian sturgeon.

International audience Telomeres shorten at each cell division due to the “end-replication problem”, but also in response to oxidative stress. Consequently telomeres shorten with age in many endotherms, and this shortening is accelerated under stressful environmental conditions. Data in ectotherm ve...

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Bibliographic Details
Published in:Physiological and Biochemical Zoology
Main Authors: Simide, Remy, Angelier, Frédéric, Gaillard, Sandrine, Stier, Antoine
Other Authors: Processus de Transfert et d'Echanges dans l'Environnement - EA 3819 (PROTEE), Université de Toulon (UTLN), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Institut National de la Recherche Agronomique (INRA)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS), Plateforme Technologique BioTechServices, Institute of Biodiversity, University of Glasgow
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2016
Subjects:
aging
review
fish
Acipenser baerii
stress
telomere
[SDE]Environmental Sciences
Siberian sturgeon
Online Access:https://hal.science/hal-01328740
https://doi.org/10.1086/687378
Description
Summary:International audience Telomeres shorten at each cell division due to the “end-replication problem”, but also in response to oxidative stress. Consequently telomeres shorten with age in many endotherms, and this shortening is accelerated under stressful environmental conditions. Data in ectotherm vertebrates remain scarce so far, so our goal was to review existing data for fish, and to test the influence of age and stress on telomere length in a very long-lived fish, the Siberian sturgeon (Acipenser baerii). Our review of the literature revealed age-related telomere shortening in approximately half of the published studies. In the Siberian sturgeon, we found a significant telomere shortening with age, both at the intra-individual level using red blood cells (-12.5% in 16 months) and at the inter-individual level using cross-sectional samples of fin over an age-range of 8 years. We also found that heat stress (30°C) significantly reduced telomere length by 15.0% after only 1 month of exposure. Our results highlight that both age and stressful environmental conditions might be important determinants of telomere length in fish.

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