Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in hu...

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Bibliographic Details
Published in:PLoS Genetics
Main Authors: Pillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipila, Kirsi, Lahdesmaki, Raija, Millwood, Iona Y., Kaakinen, Marika., Netuveli, Gopalakrishnan, Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Lisa., Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George D., Jarvelin, Marjo-Riita
Other Authors: Gibson, Greg
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science 2010
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Online Access:https://espace.library.uq.edu.au/view/UQ:321494
Description
Summary:Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P