Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step.

Bibliographic Details
Published in:Tetrahedron
Main Authors: Bachu, Prabhakar, Sperry, Jonathan, Brimble, Margaret A.
Format: Article in Journal/Newspaper
Language:English
Published: Pergamon 2008
Subjects:
Eleutherin
Thysanone
Topoisomerase II inhibitor
3C-protease inhibitor
Novozyme 4350 (Candida antarctica lipase)
Microwave assisted lipase kinetic resolution
Intramolecular cyclization
Antarc*
Antarctica
Online Access:https://espace.library.uq.edu.au/view/UQ:270765
Description
Summary:The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step.

Similar Items