The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

• Published in: Phytochemistry
• Main Authors: Herrman, Anders, Burman, Robert, Mylne, Joshua S., Karlsson, Gustav, Gullbo, Joachim, Craik, David J., Clark, Richard J., Goransson, Ulf
• Other Authors: G. P. Bolwell
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2008
• Subjects: Viola biflora L; Violaceae; Arctic yellow-violet; Two-flower violet; Cyclotides; Circular proteins; cDNA screening; Cytotoxicity; MS/MS; Anticancer; 250399 Organic Chemistry not elsewhere classified; C1; 970103 Expanding Knowledge in the Chemical Sciences; 060702 Plant Cell and Molecular Biology; Arctic; Möbius
• Online Access: https://espace.library.uq.edu.au/view/UQ:175829

The cyclotides are currently the largest known family of head-to-tail cyclic proteins. The complex structure of these small plant proteins, which consist of approximately 30 amino acid residues, contains both a circular peptide backbone and a cystine knot, the combination of which produces the cycli...