Ancient and modern genomes reveal microsatellites maintain a dynamic equilibrium through deep time

Microsatellites are widely used in population genetics, but their evolutionary dynamics remain poorly understood. It is unclear whether microsatellite loci drift in length over time. We identify more than 27 million microsatellites using a novel and unique dataset of modern and ancient Adélie pengu...

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Bibliographic Details
Main Authors: McComish, Bennet J., Charleston, Michael A., Parks, Matthew, Baroni, Carlo, Salvatore, Maria Cristina, Li, Ruiqiang, Zhang, Guojie, Millar, Craig D., Holland, Barbara R., Lambert, David M.
Other Authors: Mccomish, Bennet J.
Format: Other/Unknown Material
Language:English
Published: 2020
Subjects:
DNA
penguin guano
14C dating
Pleistocene Holocene
Antarctica
Guano
Kya
Antarc*
Online Access:http://hdl.handle.net/11568/1079423
https://doi.org/10.1101/2020.03.09.972364
https://www.biorxiv.org/content/10.1101/2020.03.09.972364v1
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Summary:Microsatellites are widely used in population genetics, but their evolutionary dynamics remain poorly understood. It is unclear whether microsatellite loci drift in length over time. We identify more than 27 million microsatellites using a novel and unique dataset of modern and ancient Adélie penguin genomes along with data from 63 published chordate genomes. We investigate microsatellite evolutionary dynamics over two time scales: one based on the Adélie penguin samples dating to approximately 46.5 kya, the other dating to the diversification of chordates more than 500 Mya. We show that the process of microsatellite allele length evolution is at dynamic equilibrium; while there is length polymorphism among individuals, the length distribution for a given locus remains stable. Many microsatellites persist over very long time scales, particularly in exons and regulatory sequence. These often retain length variability, suggesting that they may play a role in the maintenance of evolutionary plasticity.

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