Parental diuron-exposure alters offspring transcriptome and fitness in Pacific oyster Crassostrea gigas

International audience One of the primary challenges in ecotoxicology is to contribute to the assessment of the ecological status of ecosystems. In this study, we used Pacific oyster Crassostrea gigas to explore the effects of a parental exposure to diuron, a herbicide frequently detected in marine...

Full description

Bibliographic Details
Published in:Ecotoxicology and Environmental Safety
Main Authors: Bachère, Evelyne, Barranger, Audrey, Bruno, Roman, Rouxel, Julien, Menard, Dominique, Piquemal, David, Akcha, Farida
Other Authors: Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Unité Biogéochimie et Ecotoxicologie (BE), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), ACOBIOM, Diag4Zoo
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2017
Subjects:
Biomarkers
Global DNA-methylation
Herbicide
Marine bivalve
Survival
Toxicogenomics
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology
Crassostrea gigas
Pacific oyster
Online Access:https://hal.science/hal-01510956
https://hal.science/hal-01510956/document
https://hal.science/hal-01510956/file/Bachere-2017-EcotoxEnvirSaf-Parental-MANUSCRIT.pdf
https://doi.org/10.1016/j.ecoenv.2017.03.030
Description
Summary:International audience One of the primary challenges in ecotoxicology is to contribute to the assessment of the ecological status of ecosystems. In this study, we used Pacific oyster Crassostrea gigas to explore the effects of a parental exposure to diuron, a herbicide frequently detected in marine coastal environments. The present toxicogenomic study provides evidence that exposure of oyster genitors to diuron during gametogenesis results in changes in offspring, namely, transcriptomic profile alterations, increased global DNA methylation levels and reduced growth and survival within the first year of life. Importantly, we highlighted the limitations to identify particular genes or gene expression signatures that could serve as biomarkers for parental herbicide-exposure and further for multigenerational and transgenerational effects of specific chemical stressors. By analyzing samples from two independent experiments, we demonstrated that, due to complex confounding effects with both tested solvent vehicles, diuron non-specifically affected the offspring transcriptome. These original results question the potential development of predictive genomic tools for detecting specific indirect impacts of contaminants in environmental risk assessments. However, our results indicate that chronic environmental exposure to diuron over several generations may have significant long term impacts on oyster populations with adverse health outcomes.

Similar Items