Dual analysis of virus-host interactions: the case of OsHV-1 and the cupped oyster Crassostrea gigas
Dual analyses of the interactions between Ostreid herpesvirus type 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the cu...
| Published in: | Evolutionary Bioinformatics |
|---|---|
| Main Authors: | , , , , |
| Other Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
SAGE Pu.
2019
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11577/3286705 https://doi.org/10.1177/1176934319831305 |
| Summary: | Dual analyses of the interactions between Ostreid herpesvirus type 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used ‘omics’ technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 ORFs, and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of ‘omics’ technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C. gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide |
|---|