Enzymatic Preparation of Novel Aminoalkylpyridines usingLipases in Organic Solvents

A wide range of novel, enantiomericallypure 4-chloroACHTUNGTRENNUNG(amino)pyridine derivatives has beensynthesised through a chemoenzymatic approach,Candida antarctica lipase B (CAL-B) and Pseudomo-nas cepacia lipase (PSL) being found to be excellentbiocatalysts for the preparation of new and intere...

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Bibliographic Details
Published in:Advanced Synthesis & Catalysis
Main Authors: Torre González, Oliver, Busto García, Benjamín Eduardo, Gotor Fernández, Vicente, Gotor Santamaría, Vicente Miguel
Format: Article in Journal/Newspaper
Language:English
Published: 2020
Subjects:
Cierva
Antarc*
Antarctica
Online Access:http://hdl.handle.net/10651/54885
https://doi.org/10.1002/adsc.200600634
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Summary:A wide range of novel, enantiomericallypure 4-chloroACHTUNGTRENNUNG(amino)pyridine derivatives has beensynthesised through a chemoenzymatic approach,Candida antarctica lipase B (CAL-B) and Pseudomo-nas cepacia lipase (PSL) being found to be excellentbiocatalysts for the preparation of new and interest-ing amines and amides in enantiomerically pureform through enzymatic aminolysis reactions. Astudy of the enzymatic reactivity of CAL-B and PSLhas been done in the resolution of a library of aminestructures in an attempt to rationalise the experimen-tal results obtained in their enzymatic kinetic resolu-tion mediated by lipases Financial support of this work by the European Project EU-04-LSHB-2003–503017 and the Principado de Asturias (IB-05–109) is gratefully acknowledged. V. G.-F. and E. B thankMinisterio de Educación y Ciencia for a personal grant (Juande la Cierva Program), and a pre-doctoral fellowship respec-tively.

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