| Summary: | Abstract Early family characteristics may influence the later development of severe mental disorders and criminality of a child. The association between an adverse family environment during childhood and its later consequences in adulthood, however, are still widely open. The aim of the present study was to analyse in a longitudinal perspective, family risks of severe hospital-treated mental disorders and criminal behaviour in the Northern Finland 1966 Birth Cohort and to develop a descriptive life span model of schizophrenia. A large, general population birth cohort (N =11 017), the Northern Finland 1966 Birth Cohort was used as a study population. This database provides the information of prospectively collected data on both biological and social aspects of pregnancy, the characteristics of family, the mother, the father, and the child. The information of psychiatric outcomes was gathered from the Finnish Hospital Discharge Register (FHDR) and the data on registered criminal behaviour of the cohort members come from computerized files maintained by the Ministry of Justice. Children born to multiparous mothers (GMP) i.e. those that had undergone at least six deliveries were more commonly treated in mental hospitals later in life (4.5% vs. 3.4%; p=0.028) than children born to mothers that have fewer children. Of the diagnostic groups, the risk of psychoses other than schizophrenia (OR 2.3; 95% CI 1.2–4.7), and depressive disorders (OR 2.2; 1.0–4.5) was elevated among adult children of those mothers. Birth order was associated with adult schizophrenia. The risk was elevated among male firstborns (ratio 1.5; 95% CI 1.0–2.2), but it was lower than expected among male lastborns (ratio 0.7; 95% CI 0.5–0.9). The elevated risk was not significantly associated with female schizophrenia patients. On the contrary, the risk was lower than expected among females who were not first, not last or not only children in the family (ratio 0.6; 95% CI 0.3–0.9). Among males the risk for violent crimes later in life was elevated ...
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