| Summary: | The aim of this study was to determine the levels of catalase in the brain of Rattus rattus var. albinus with ketamine-induced psychotic behavior in four study groups. The first is the control which received saline, the problem I received 15 mg / kg, the problem II received 30 mg / kg and the problem III group received 45 mg / kg. Psychotic behavior was evaluated for 20 days using two Open Field and Rota Rod models. The variables analyzed in the Open Field were square advanced, bipedal, and self-cleaning time position; and Rota Rod was the residence time. The Rota Rod was measured in the first seven days after one hour of administration. The Open Field was measured on days 1, 2, 4, 6, 8, 10 and 20 on the first day was measured at 0.5, 1.0, 2.5 and 4.5 hours.; on other days was analyzed once a day. He finished 20 days proceeded to slaughter the animals and spread the brain for subsequent determination of catalase and histopathology. The results obtained with the model Open Field were increased in all three groups locomotion problems compared with the control group. Regarding the Rota Rod the result after performing this analysis was that ketamine produces a longer residence time of the specimens in the Rota Rod. In the determination of catalase was observed a tendency to increase in the problem that enzyme I, II and III; compared to control; observed a statistical difference (p <0.05) in group III problem. Similarly the link increased hyperlocomotion catalase with a strong bearing on the problem III with a significant difference (p <0.05) was observed. Finally using histopathology changes such as severe chromatolysis, reactive astrogliosis, oligodendroglial satellitosis were observed. In conclusion, our study provides evidence that the dose 45 mg / kg significantly increased levels of catalase in brain specimens and is the best to watch hyperlocomotion El objetivo del presente estudio fue determinar los niveles de catalasa en el cerebro de Rattus rattus var. albinus con comportamiento psicótico inducido ...
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